Stochastic expression dynamics of a transcription factor revealed by single-molecule noise analysis


Gene expression is inherently stochastic; precise gene regulation by transcription factors is important for cell-fate determination. Many transcription factors regulate their own expression, suggesting that autoregulation counters intrinsic stochasticity in gene expression. Using a new strategy, cotranslational activation by cleavage (CoTrAC), we probed the… (More)
DOI: 10.1038/nsmb.2336


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Citations per Year

Citation Velocity: 22

Averaging 22 citations per year over the last 3 years.

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