Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification.

@article{Atkins2011StochasticEC,
  title={Stochastic ensembles, conformationally adaptive teamwork, and enzymatic detoxification.},
  author={William M Atkins and H. P. Qian},
  journal={Biochemistry},
  year={2011},
  volume={50 19},
  pages={3866-72}
}
It has been appreciated for a long time that enzymes exist as conformational ensembles throughout multiple stages of the reactions they catalyze, but there is renewed interest in the functional implications. The energy landscape that results from conformationlly diverse poteins is a complex surface with an energetic topography in multiple dimensions, even… CONTINUE READING