Stochastic control of metabolic pathways

  title={Stochastic control of metabolic pathways},
  author={Andrea Rocco},
  journal={Physical Biology},
  • A. Rocco
  • Published 1 March 2009
  • Computer Science
  • Physical Biology
We study the effect of extrinsic noise in metabolic networks. We introduce external random fluctuations at the kinetic level, and show how these lead to a stochastic generalization of standard metabolic control analysis. While summation and connectivity theorems hold true in the presence of extrinsic noise, control coefficients incorporate its effect through an explicit dependency on the noise intensity. New elasticities and response coefficients are also defined. Accordingly, the concept of… 

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  • E. LevineT. Hwa
  • Biology
    Proceedings of the National Academy of Sciences
  • 2007
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