Stochastic cancer progression driven by non‐clonal chromosome aberrations

@article{Heng2006StochasticCP,
  title={Stochastic cancer progression driven by non‐clonal chromosome aberrations},
  author={Henry H. Q. Heng and Joshua B. Stevens and Gou Liu and Steven W. Bremer and Karen J. Ye and Prem Veer Reddy and Gen Sheng Wu and Y. Alan Wang and Michael A. Tainsky and Christine J. Ye},
  journal={Journal of Cellular Physiology},
  year={2006},
  volume={208}
}
Cancer research has previously focused on the identification of specific genes and pathways responsible for cancer initiation and progression based on the prevailing viewpoint that cancer is caused by a stepwise accumulation of genetic aberrations. This viewpoint, however, is not consistent with the clinical finding that tumors display high levels of genetic heterogeneity and distinctive karyotypes. We show that chromosomal instability primarily generates stochastic karyotypic changes leading… 

Cancer progression by non‐clonal chromosome aberrations

It is argued that even though stochastic changes can be detected at various levels of genetic organization, such as at the gene level and epigenetic level, it is primarily detected at the chromosomal or genome level, and thus, NCCA‐mediated genomic variation plays a dominant role in cancer progression.

Clonal and non-clonal chromosome aberrations and genome variation and aberration.

This study raises challenging questions regarding the concept of cancer evolution driven by stochastic chromosomal aberration mediated genome irregularities that could have repercussions reaching far beyond cancer and organismal genomes.

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This conceptual piece briefly discusses some of the recent exciting progress in the field of cancer genomics and genome research, and lists various types of non-recurrent chromosomal aberrations, and discusses the likely mechanism underlying cancer chromosome dynamics.

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  • H. HengJ. Stevens C. Ye
  • Biology
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  • 2008
The importance of the chromosome versus the gene as a causative agent in cancer formation has sparked a heated debate and the existence of an overwhelming amount of non-clonal chromosome aberrations (NCCAs) has been identified in patients and cancer progression models.

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For decades the conventional gene mutation cancer theory has been postulating that cancer is a genetic disease considered as a result of deterministic sequential accumulation of mutations in the

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The inheritance of heterogeneity

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New Insights in the Cytogenetic Practice: Karyotypic Chaos, Non-Clonal Chromosomal Alterations and Chromosomal Instability in Human Cancer and Therapy Response

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...

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Cancer progression by non‐clonal chromosome aberrations

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