Stochastic bistability and bifurcation in a mesoscopic signaling system with autocatalytic kinase.

@article{Bishop2010StochasticBA,
  title={Stochastic bistability and bifurcation in a mesoscopic signaling system with autocatalytic kinase.},
  author={Lisa M. Bishop and H. P. Qian},
  journal={Biophysical journal},
  year={2010},
  volume={98 1},
  pages={1-11}
}
Bistability is a nonlinear phenomenon widely observed in nature including in biochemical reaction networks. Deterministic chemical kinetics studied in the past has shown that bistability occurs in systems with strong (cubic) nonlinearity. For certain mesoscopic, weakly nonlinear (quadratic) biochemical reaction systems in a small volume, however, stochasticity can induce bistability and bifurcation that have no macroscopic counterpart. We report the simplest yet known reactions involving driven… CONTINUE READING
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