Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

@article{Herndon2002StochasticAG,
  title={Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans},
  author={Laura A. Herndon and Peter J. Schmeissner and Justyna M. Dudaronek and Paula A. Brown and Kristin M. Listner and Yuko Sakano and Marie C. Paupard and David H. Hall and Monica Driscoll},
  journal={Nature},
  year={2002},
  volume={419},
  pages={808-814}
}
The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis and visualization of specific cell types with green fluorescent protein, we examined cell integrity in different tissues as the animal ages. We report remarkable preservation of the… CONTINUE READING
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