Stochastic analysis of bistability in coherent mixed feedback loops combining transcriptional and posttranscriptional regulations.

  title={Stochastic analysis of bistability in coherent mixed feedback loops combining transcriptional and posttranscriptional regulations.},
  author={Mor Nitzan and Yishai Shimoni and Oded Rosolio and Hanah Margalit and Ofer Biham},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  volume={91 5},
  • M. NitzanY. Shimoni O. Biham
  • Published 2 December 2014
  • Biology
  • Physical review. E, Statistical, nonlinear, and soft matter physics
Mixed feedback loops combining transcriptional and posttranscriptional regulations are common in cellular regulatory networks. They consist of two genes, encoding a transcription factor and a small noncoding RNA (sRNA), which mutually regulate each other's expression. We present a theoretical and numerical study of coherent mixed feedback loops of this type, in which both regulations are negative. Under suitable conditions, these feedback loops are expected to exhibit bistability, namely, two… 

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