Stochastic Modeling and Control of Biological Systems: The Lactose Regulation System of Escherichia Coli

@article{Julius2008StochasticMA,
  title={Stochastic Modeling and Control of Biological Systems: The Lactose Regulation System of Escherichia Coli},
  author={Anak Agung Julius and {\'A}d{\'a}m M. Hal{\'a}sz and Mahmut Selman Sakar and Harvey Rubin and V. S. Anil Kumar and George J. Pappas},
  journal={IEEE Transactions on Automatic Control},
  year={2008},
  volume={53},
  pages={51-65}
}
In this paper, we present a comprehensive framework for stochastic modeling, model abstraction, and controller design for a biological system. The first half of the paper concerns modeling and model abstraction of the system. Most models in systems biology are deterministic models with ordinary differential equations in the concentration variables. We present a stochastic hybrid model of the lactose regulation system of E. coli bacteria that capture important phenomena which cannot be described… CONTINUE READING

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