Stochastic Gene Expression in a Single Cell

@article{Elowitz2002StochasticGE,
  title={Stochastic Gene Expression in a Single Cell},
  author={M. Elowitz and A. Levine and E. Siggia and P. Swain},
  journal={Science},
  year={2002},
  volume={297},
  pages={1183 - 1186}
}
  • M. Elowitz, A. Levine, +1 author P. Swain
  • Published 2002
  • Biology, Medicine
  • Science
  • Clonal populations of cells exhibit substantial phenotypic variation. Such heterogeneity can be essential for many biological processes and is conjectured to arise from stochasticity, or noise, in gene expression. We constructed strains of Escherichia coli that enable detection of noise and discrimination between the two mechanisms by which it is generated. Both stochasticity inherent in the biochemical process of gene expression (intrinsic noise) and fluctuations in other cellular components… CONTINUE READING
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    References

    SHOWING 1-10 OF 60 REFERENCES
    Intrinsic noise in gene regulatory networks
    • 1,341
    • PDF
    Engineering stability in gene networks by autoregulation
    • 1,398
    • PDF
    Induction mechanism of a single gene molecule: stochastic or deterministic?
    • M. Ko
    • Biology, Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 1992
    • 111
    Stochastic mechanisms in gene expression.
    • H. McAdams, A. Arkin
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1997
    • 1,797
    • PDF
    To be or not to be active: the stochastic nature of enhancer action.
    • 167
    • PDF
    A synthetic oscillatory network of transcriptional regulators
    • 3,913
    • PDF
    Robustness in bacterial chemotaxis
    • 1,084
    • PDF
    Does replication-induced transcription regulate synthesis of the myriad low copy number proteins of Escherichia coli?
    • P. Guptasarma
    • Biology, Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 1995
    • 146
    Non-genetic individuality: chance in the single cell
    • 490
    • PDF