Stochastic Gene Expression in a Single Cell

  title={Stochastic Gene Expression in a Single Cell},
  author={M. Elowitz and A. Levine and E. Siggia and P. Swain},
  pages={1183 - 1186}
  • M. Elowitz, A. Levine, +1 author P. Swain
  • Published 2002
  • Biology, Medicine
  • Science
  • Clonal populations of cells exhibit substantial phenotypic variation. Such heterogeneity can be essential for many biological processes and is conjectured to arise from stochasticity, or noise, in gene expression. We constructed strains of Escherichia coli that enable detection of noise and discrimination between the two mechanisms by which it is generated. Both stochasticity inherent in the biochemical process of gene expression (intrinsic noise) and fluctuations in other cellular components… CONTINUE READING
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