Stn1 is critical for telomere maintenance and long-term viability of somatic human cells

@inproceedings{Boccardi2015Stn1IC,
  title={Stn1 is critical for telomere maintenance and long-term viability of somatic human cells},
  author={Virginia Boccardi and Neetu Razdan and Jessica M. Kaplunov and Jyoti Joshi Mundra and Masayuki Kimura and Abraham Aviv and Utz Herbig},
  booktitle={Aging cell},
  year={2015}
}
Disruption of telomere maintenance pathways leads to accelerated entry into cellular senescence, a stable proliferative arrest that promotes aging-associated disorders in some mammals. The budding yeast CST complex, comprising Cdc13, Stn1, and Ctc1, is critical for telomere replication, length regulation, and end protection. Although mammalian homologues of CST have been identified recently, their role and function for telomere maintenance in normal somatic human cells are still incompletely… CONTINUE READING
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Evolution of CST function in telomere maintenance.

Cell cycle • 2010
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