Stiripentol in the Management of Epilepsy

@article{Nickels2017StiripentolIT,
  title={Stiripentol in the Management of Epilepsy},
  author={Katherine C. Nickels and Elaine C. Wirrell},
  journal={CNS Drugs},
  year={2017},
  volume={31},
  pages={405-416}
}
Stiripentol is a structurally unique antiepileptic drug that has several possible mechanisms of action, including diverse effects on the gamma-aminobutyric acid (GABA)-A receptor and novel inhibition of lactate dehydrogenase. Because of its inhibition of several cytochrome P450 enzymes, it has extensive pharmacokinetic interactions, which often necessitates reduction in doses of certain co-therapies, particularly clobazam. Stiripentol also has a neuroprotective action, by reducing calcium… 
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