Stiripentol in the Management of Epilepsy

@article{Nickels2017StiripentolIT,
  title={Stiripentol in the Management of Epilepsy},
  author={Katherine C. Nickels and Elaine C. Wirrell},
  journal={CNS Drugs},
  year={2017},
  volume={31},
  pages={405-416}
}
Stiripentol is a structurally unique antiepileptic drug that has several possible mechanisms of action, including diverse effects on the gamma-aminobutyric acid (GABA)-A receptor and novel inhibition of lactate dehydrogenase. Because of its inhibition of several cytochrome P450 enzymes, it has extensive pharmacokinetic interactions, which often necessitates reduction in doses of certain co-therapies, particularly clobazam. Stiripentol also has a neuroprotective action, by reducing calcium… 
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Therapeutic effects of stiripentol against ischemia-reperfusion injury in gerbils focusing on cognitive deficit, neuronal death, astrocyte damage and blood brain barrier leakage in the hippocampus
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  • Medicine
    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2022
TLDR
Results of this study suggest stiripentol can be developed as a candidate of therapeutic drug for ischemic stroke, showing that pyramidal neurons were protected and astrocyte damage and blood brain barrier leakage were significantly attenuated in the hippocampus.
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