Stiripentol in the Management of Epilepsy

@article{Nickels2017StiripentolIT,
  title={Stiripentol in the Management of Epilepsy},
  author={Katherine C. Nickels and Elaine C. Wirrell},
  journal={CNS Drugs},
  year={2017},
  volume={31},
  pages={405-416}
}
Stiripentol is a structurally unique antiepileptic drug that has several possible mechanisms of action, including diverse effects on the gamma-aminobutyric acid (GABA)-A receptor and novel inhibition of lactate dehydrogenase. Because of its inhibition of several cytochrome P450 enzymes, it has extensive pharmacokinetic interactions, which often necessitates reduction in doses of certain co-therapies, particularly clobazam. Stiripentol also has a neuroprotective action, by reducing calcium… 
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Stiripentol: A Review in Dravet Syndrome
TLDR
Based on the available evidence, stiripentol, as an adjunct to clobazam and valproate, is a demonstrably beneficial and generally well-tolerated second-line treatment for patients with DS.
Stiripentol for the treatment of seizures associated with Dravet syndrome
  • C. Chiron
  • Psychology, Medicine
    Expert review of neurotherapeutics
  • 2019
TLDR
Stiripentol could be especially useful in two critical conditions of the disease, very young age (<2 years) and convulsive status epilepticus, and seizure freedom seems occasionally be obtained with fenfluramine.
Lorcaserin for Dravet Syndrome: A Potential Advance Over Fenfluramine?
TLDR
Preliminary uncontrolled studies in patients with Dravet syndrome have yielded promising results, and a phase III, double-blind, placebo-controlled, parallel group trial is currently ongoing to assess its efficacy and safety in children and adults with Draket syndrome.
Antiepileptic Drugs in Pediatrics.
TLDR
The history and evolution of AED development, features of specific AEDs with a focus on the newest generation, and examples of Aeds in development are reviewed.
Pharmacokinetic considerations for anti-epileptic drugs in children
TLDR
The main pharmacokinetic characteristics of AEDs used in children are reviewed, focusing on age-related factors which are of relevance when treating this patient population, especially in children.
Pharmacokinetics and Drug Interaction of Antiepileptic Drugs in Children and Adolescents
TLDR
The mechanism of action, pharmacokinetics, drug–drug interactions, and safety/tolerability profiles of the main AEDs currently used in children and adolescents are reviewed, paying particular regard to issues of relevance when treating this patient population.
Pharmacokinetic Drug–Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients
TLDR
The purpose of this review is to present data from the last few years on drug–drug interactions among of Aeds, as well as AEDs with other drugs, nutrients and food, and to pay a special attention to the new potential interactions of the applied first-generation AEDS.
A Practical Guide to the Treatment of Dravet Syndrome with Anti-Seizure Medication
TLDR
This practical guide provides an overview of three adjunct ASMs for the treatment of seizures in patients with Dravet syndrome including their indications/contraindications, mechanism of action, efficacy, safety and tolerability profile, dosage requirements, and laboratory and clinical parameters to be evaluated.
The role of new medical treatments for the management of developmental and epileptic encephalopathies: Novel concepts and results
TLDR
An overview of new medical treatment options for developmental and epileptic encephalopathies is provided and the clinical implications of these results for improved treatment are discussed.
Stiripentol in the treatment of adults with focal epilepsy- a retrospective analysis
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References

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TLDR
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TLDR
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TLDR
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TLDR
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