Stiripentol in the Management of Epilepsy
@article{Nickels2017StiripentolIT, title={Stiripentol in the Management of Epilepsy}, author={Katherine C. Nickels and Elaine C. Wirrell}, journal={CNS Drugs}, year={2017}, volume={31}, pages={405-416} }
Stiripentol is a structurally unique antiepileptic drug that has several possible mechanisms of action, including diverse effects on the gamma-aminobutyric acid (GABA)-A receptor and novel inhibition of lactate dehydrogenase. Because of its inhibition of several cytochrome P450 enzymes, it has extensive pharmacokinetic interactions, which often necessitates reduction in doses of certain co-therapies, particularly clobazam. Stiripentol also has a neuroprotective action, by reducing calcium…
22 Citations
Stiripentol: A Review in Dravet Syndrome
- MedicineDrugs
- 2019
Based on the available evidence, stiripentol, as an adjunct to clobazam and valproate, is a demonstrably beneficial and generally well-tolerated second-line treatment for patients with DS.
Stiripentol for the treatment of seizures associated with Dravet syndrome
- Psychology, MedicineExpert review of neurotherapeutics
- 2019
Stiripentol could be especially useful in two critical conditions of the disease, very young age (<2 years) and convulsive status epilepticus, and seizure freedom seems occasionally be obtained with fenfluramine.
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Preliminary uncontrolled studies in patients with Dravet syndrome have yielded promising results, and a phase III, double-blind, placebo-controlled, parallel group trial is currently ongoing to assess its efficacy and safety in children and adults with Draket syndrome.
Antiepileptic Drugs in Pediatrics.
- Psychology, MedicineHandbook of experimental pharmacology
- 2019
The history and evolution of AED development, features of specific AEDs with a focus on the newest generation, and examples of Aeds in development are reviewed.
Pharmacokinetic considerations for anti-epileptic drugs in children
- MedicineExpert opinion on drug metabolism & toxicology
- 2019
The main pharmacokinetic characteristics of AEDs used in children are reviewed, focusing on age-related factors which are of relevance when treating this patient population, especially in children.
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- Medicine, BiologyPediatric Drugs
- 2018
The mechanism of action, pharmacokinetics, drug–drug interactions, and safety/tolerability profiles of the main AEDs currently used in children and adolescents are reviewed, paying particular regard to issues of relevance when treating this patient population.
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- Medicine, BiologyInternational journal of molecular sciences
- 2021
The purpose of this review is to present data from the last few years on drug–drug interactions among of Aeds, as well as AEDs with other drugs, nutrients and food, and to pay a special attention to the new potential interactions of the applied first-generation AEDS.
A Practical Guide to the Treatment of Dravet Syndrome with Anti-Seizure Medication
- MedicineCNS Drugs
- 2022
This practical guide provides an overview of three adjunct ASMs for the treatment of seizures in patients with Dravet syndrome including their indications/contraindications, mechanism of action, efficacy, safety and tolerability profile, dosage requirements, and laboratory and clinical parameters to be evaluated.
The role of new medical treatments for the management of developmental and epileptic encephalopathies: Novel concepts and results
- MedicineEpilepsia
- 2021
An overview of new medical treatment options for developmental and epileptic encephalopathies is provided and the clinical implications of these results for improved treatment are discussed.
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- Medicine, PsychologySeizure
- 2021
References
SHOWING 1-10 OF 57 REFERENCES
The effects of stiripentol on GABAA receptors
- BiologyEpilepsia
- 2011
Positive modulation by stiripentol was most effective at GABAA receptors containing an α3 subunit, which is developmentally regulated, with highest levels in the immature brain, and may explain the greater clinical efficacy of stiripENTol in childhood‐onset epilepsies, including Dravet syndrome.
Stiripentol. A novel antiepileptic drug.
- Biology, MedicinePharmacological reports : PR
- 2005
STP potentiates central gamma-aminobutyric acid (GABA) transmission and is characterized by nonlinear pharmacokinetics and inhibition of liver microsomal enzymes, and seems a good candidate for adjunctive therapy in intractable epilepsy.
The efficacy of bromides, stiripentol and levetiracetam in two patients with malignant migrating partial seizures in infancy
- Medicine, PsychologyEpileptic disorders : international epilepsy journal with videotape
- 2011
Antiepileptic drugs, previously reported to be beneficial in case reports, when given concomitantly, may substantially reduce the number and severity of seizures, without influence on psychomotor development.
Combination of ketogenic diet and stiripentol for super-refractory status epilepticus: A case report
- Medicine, BiologyJournal of the Neurological Sciences
- 2017
Stiripentol, a Putative Antiepileptic Drug, Enhances the Duration of Opening of GABAA‐Receptor Channels
- Biology, MedicineEpilepsia
- 2006
Stiripentol is currently an efficient drug for add‐on therapy in infantile epilepsies because it improves the efficacy of antiepileptic drugs (AEDs) through its potent inhibition of liver cytochromes P450.
The anti-convulsant stiripentol acts directly on the GABAA receptor as a positive allosteric modulator
- BiologyNeuropharmacology
- 2009
Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial
- Medicine, PsychologyThe Lancet
- 2000
Stiripentol
- Medicine, PsychologyNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
- 2005
The trials conducted in paediatric populations demonstrated a specific efficacy of STP in a severe form of early childhood epilepsy, Dravet syndrome, when combined with valproate and clobazam, and the French experience in compassionate use suggests that STP might also be of benefit when Combined with carbamazepine in children with pharmacoresistant partial epilepsy.
Stiripentol in refractory status epilepticus
- Biology, PsychologyEpilepsia
- 2013
It is suggested that STP, either alone or as add‐on therapy, may prove useful in treating established and BZD‐resistant status epilepticus and may be particularly effective in terminating SE in children when SE is most prevalent.
Stiripentol in Atypical Absence Seizures in Children: An Open Trial
- Medicine, PsychologyEpilepsia
- 1993
Stiripentol (STP) was added to the antiepileptic drug (AED) regimen of 10 patients with uncontrolled atypical absence seizures (more than one seizure a day) and it is concluded that STP shows promise in treatment of atypicals absence seizures in children.