Stiripentol in the Management of Epilepsy

@article{Nickels2017StiripentolIT,
  title={Stiripentol in the Management of Epilepsy},
  author={Katherine C. Nickels and Elaine C. Wirrell},
  journal={CNS Drugs},
  year={2017},
  volume={31},
  pages={405-416}
}
Stiripentol is a structurally unique antiepileptic drug that has several possible mechanisms of action, including diverse effects on the gamma-aminobutyric acid (GABA)-A receptor and novel inhibition of lactate dehydrogenase. Because of its inhibition of several cytochrome P450 enzymes, it has extensive pharmacokinetic interactions, which often necessitates reduction in doses of certain co-therapies, particularly clobazam. Stiripentol also has a neuroprotective action, by reducing calcium… 
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Stiripentol: A Review in Dravet Syndrome
TLDR
Based on the available evidence, stiripentol, as an adjunct to clobazam and valproate, is a demonstrably beneficial and generally well-tolerated second-line treatment for patients with DS.
Stiripentol for the treatment of seizures associated with Dravet syndrome
  • C. Chiron
  • Medicine
    Expert review of neurotherapeutics
  • 2019
TLDR
Stiripentol could be especially useful in two critical conditions of the disease, very young age (<2 years) and convulsive status epilepticus, and seizure freedom seems occasionally be obtained with fenfluramine.
Antiepileptic Drugs in Pediatrics.
TLDR
The history and evolution of AED development, features of specific AEDs with a focus on the newest generation, and examples of Aeds in development are reviewed.
Pharmacokinetic considerations for anti-epileptic drugs in children
TLDR
The main pharmacokinetic characteristics of AEDs used in children are reviewed, focusing on age-related factors which are of relevance when treating this patient population, especially in children.
Pharmacokinetics and Drug Interaction of Antiepileptic Drugs in Children and Adolescents
TLDR
The mechanism of action, pharmacokinetics, drug–drug interactions, and safety/tolerability profiles of the main AEDs currently used in children and adolescents are reviewed, paying particular regard to issues of relevance when treating this patient population.
Pharmacokinetic Drug–Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients
TLDR
The purpose of this review is to present data from the last few years on drug–drug interactions among of Aeds, as well as AEDs with other drugs, nutrients and food, and to pay a special attention to the new potential interactions of the applied first-generation AEDS.
The role of new medical treatments for the management of developmental and epileptic encephalopathies: Novel concepts and results
TLDR
An overview of new medical treatment options for developmental and epileptic encephalopathies is provided and the clinical implications of these results for improved treatment are discussed.
Stiripentol in the treatment of adults with focal epilepsy- a retrospective analysis
TLDR
STP seems to be a useful option in the treatment of patients with severely pharmacoresistant epilepsy, and Prospective trials are necessary to examine the efficacy of STP in adult patients with pharmacoreistant focal epilepsy.
Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review
TLDR
Important background information is gathered on LC methods that have been developed and applied for the determination of perampanel, retigabine, rufinamide and stiripentol, which should be considered as a starting point if new (bio)analytical techniques are aimed to be implemented for these drugs.
Therapeutic effects of stiripentol against ischemia-reperfusion injury in gerbils focusing on cognitive deficit, neuronal death, astrocyte damage and blood brain barrier leakage in the hippocampus
  • Myoung Cheol Shin, Tae-Kyeong Lee, +7 authors Choong Hyun Lee
  • Medicine
    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2022
TLDR
Results of this study suggest stiripentol can be developed as a candidate of therapeutic drug for ischemic stroke, showing that pyramidal neurons were protected and astrocyte damage and blood brain barrier leakage were significantly attenuated in the hippocampus.
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References

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TLDR
Positive modulation by stiripentol was most effective at GABAA receptors containing an α3 subunit, which is developmentally regulated, with highest levels in the immature brain, and may explain the greater clinical efficacy of stiripENTol in childhood‐onset epilepsies, including Dravet syndrome.
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TLDR
STP potentiates central gamma-aminobutyric acid (GABA) transmission and is characterized by nonlinear pharmacokinetics and inhibition of liver microsomal enzymes, and seems a good candidate for adjunctive therapy in intractable epilepsy.
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Antiepileptic drugs, previously reported to be beneficial in case reports, when given concomitantly, may substantially reduce the number and severity of seizures, without influence on psychomotor development.
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TLDR
It is reported that a combination of KD and STP appeared to constitute effective treatment of a patient with SRSE underlying anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.
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TLDR
Stiripentol is currently an efficient drug for add‐on therapy in infantile epilepsies because it improves the efficacy of antiepileptic drugs (AEDs) through its potent inhibition of liver cytochromes P450.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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