Stimulus-specific inhibition of insulin release from rat pancreas by both rat and porcine galanin.

@article{Verchere1992StimulusspecificIO,
  title={Stimulus-specific inhibition of insulin release from rat pancreas by both rat and porcine galanin.},
  author={C Bruce Verchere and Yin Nam Kwok and John Canvin Brown},
  journal={Life sciences},
  year={1992},
  volume={51 25},
  pages={
          1945-51
        }
}
The effect of the neuropeptide galanin on insulin and somatostatin secretion in the rat was studied under various conditions. In the perfused rat pancreas, insulin secretion stimulated by arginine, but not cholecystokinin-8 (CCK-8) or acetylcholine (ACh) was inhibited by both rat and porcine galanin, whereas ACh-stimulated somatostatin release was inhibited by rat but not porcine galanin. Neither arginine nor CCK-8 significantly altered somatostatin secretion and galanin was without effect… CONTINUE READING

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