Stimulus-secretion coupling of arginine-induced insulin release. Insulinotropic action of agmatine.

@article{Sener1989StimulussecretionCO,
  title={Stimulus-secretion coupling of arginine-induced insulin release. Insulinotropic action of agmatine.},
  author={A. Sener and P. Lebrun and F. Blachier and W. Malaisse},
  journal={Biochemical pharmacology},
  year={1989},
  volume={38 2},
  pages={
          327-30
        }
}
Agmatine causes a concentration-related (0.1-1.0 mM) stimulation of insulin secretion by rat pancreatic islets exposed to D-glucose (5.6-11.1 mM) but, like L-arginine, fails to affect insulin release either in the absence of glucose or at a high concentration (16.7 mM) of the hexose. Agmatine, which accumulates in islet cells, also stimulates 45Ca net uptake by the islets. The secretory response to agmatine represents a delayed process. It is enhanced by theophylline and suppressed by antimycin… Expand
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