Stimulus-secretion coupling of arginine-induced insulin release. Metabolism of L-arginine and L-ornithine in pancreatic islets.

@article{Malaisse1989StimulussecretionCO,
  title={Stimulus-secretion coupling of arginine-induced insulin release. Metabolism of L-arginine and L-ornithine in pancreatic islets.},
  author={Willy Jean Malaisse and François Blachier and Aref Mourtada and Joaquin Camara and A. Albor and Isabel Valverde and Abdullah Sener},
  journal={Biochimica et biophysica acta},
  year={1989},
  volume={1013 2},
  pages={133-43}
}
Exogenous L-arginine and L-ornithine rapidly accumulate in rat pancreatic islets. L-Arginine is converted to L-ornithine and urea. Endogenous or exogenous L-ornithine generates di- and polyamines, the putrescine turnover being faster than that of spermidine and spermine. However, the major pathway for L-ornithine metabolism consists of its transamination to L-glutamaldehyde and further conversion to L-glutamate. The amines and L-glutamate derived from exogenous L-ornithine are incorporated into… CONTINUE READING

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