Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.

@article{MacEwan2010StimulusresponsiveMA,
  title={Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.},
  author={Sarah R MacEwan and Daniel Joseph Callahan and Ashutosh Chilkoti},
  journal={Nanomedicine},
  year={2010},
  volume={5 5},
  pages={
          793-806
        }
}
Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Stimulus-responsive peptide and polymer vehicles can further enhance the efficacy of antitumor therapeutics compared with the administration of free drug by three mechanisms: increasing the overall accumulation within solid tumors; providing a homogeneous spatial distribution in tumor… CONTINUE READING
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