Stimulus perception in bacterial signal-transducing histidine kinases.

  title={Stimulus perception in bacterial signal-transducing histidine kinases.},
  author={Thorsten Mascher and John D. Helmann and Gottfried Unden},
  journal={Microbiology and molecular biology reviews : MMBR},
  volume={70 4},
Two-component signal-transducing systems are ubiquitously distributed communication interfaces in bacteria. They consist of a histidine kinase that senses a specific environmental stimulus and a cognate response regulator that mediates the cellular response, mostly through differential expression of target genes. Histidine kinases are typically transmembrane proteins harboring at least two domains: an input (or sensor) domain and a cytoplasmic transmitter (or kinase) domain. They can be… CONTINUE READING
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