Stimulus effects of ibogaine in rats trained with yohimbine, DOM, or LSD

@article{Palumbo1992StimulusEO,
  title={Stimulus effects of ibogaine in rats trained with yohimbine, DOM, or LSD},
  author={Patricia A. Palumbo and J. C. Winter},
  journal={Pharmacology Biochemistry and Behavior},
  year={1992},
  volume={43},
  pages={1221-1226}
}
The stimulus effects of ibogaine were compared with those of yohimbine, an alpha 2-adrenoceptor antagonist, 2,5-dimethoxy-4-methylamphetamine (DOM), a 5-hydroxytryptamine2 (5-HT2) agonist, and lysergic acid diethylamide (LSD), a nonspecific 5-HT agonist. Rats were trained with either yohimbine (6 mg/kg), DOM (0.6 mg/kg), or LSD (0.1 mg/kg) vs. no treatment in a two-lever discrimination task. Tests of generalization were then conducted with ibogaine. In yohimbine-trained animals, 39.7% of… Expand
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