Stimulus-dependent inhibition of superoxide generation by prostaglandins.

@article{Sedgwick1985StimulusdependentIO,
  title={Stimulus-dependent inhibition of superoxide generation by prostaglandins.},
  author={Julie B. Sedgwick and Martine B{\'e}rub{\'e} and Robert B. Zurier},
  journal={Clinical immunology and immunopathology},
  year={1985},
  volume={34 2},
  pages={
          205-15
        }
}
  • Julie B. Sedgwick, Martine Bérubé, Robert B. Zurier
  • Published in
    Clinical immunology and…
    1985
  • Biology, Medicine
  • Infiltrating phagocytes generate superoxide anion (O2-) and prostaglandin (PG) at sites of inflammation. Thus PG-O2- interactions may be important to the initiation and control of inflammation. PGE1, PGE2, and PGD2 inhibit O2- generation (as measured by superoxide dismutase-inhibitable reduction of ferricytochrome c) in a dose-dependent manner (10(-6)-10(-9) M) when human peripheral blood polymorphonuclear leucocytes (PMN) are stimulated with 10(-7) M of the chemotactic peptide, N-formyl… CONTINUE READING

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