Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways.

@article{Whitehurst2004StimuluscoupledSR,
  title={Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways.},
  author={Angelique Whitehurst and Melanie H Cobb and Michael A. White},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 23},
  pages={10145-50}
}
Current understanding of cell regulatory systems suggests a diverse array of extracellular stimuli commonly recruit a limited cadre of core signal transduction modules to drive discrete stimulus-specific responses. One such module is the Raf-MEK-extracellular signal-regulated kinase (ERK) kinase cascade. Little information exists about how this pathway can be appropriately coupled to discrete cell biological processes. Contributing factors may include regulation of the duration, amplitude, and… CONTINUE READING

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