Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells.

@article{Nochi2008StimulatoryRO,
  title={Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells.},
  author={Hiromi Nochi and Hideaki Tomura and Masayuki Tobo and Nobuyuki Tanaka and Koichi Sato and Tetsuya Shinozaki and Tsutomu Kobayashi and Kenji Takagishi and Hideo Ohta and Fumikazu Okajima and Koichi Tamoto},
  journal={Journal of immunology},
  year={2008},
  volume={181 7},
  pages={5111-9}
}
While inflammatory cytokines are well-recognized critical factors for the induction of cyclooxygenase-2 (COX-2) in activated fibroblast-like synovial cells, the roles of biologically active components other than inflammatory cytokines in synovial fluid remain unknown. Herein, we assessed the role of lysophosphatidic acid (LPA), a pleiotropic lipid mediator, in COX-2 induction using synovial fluid of patients with rheumatoid arthritis (RA) in fibroblast-like RA synovial cells. Synovial fluid… CONTINUE READING
25 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…