Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase.

@article{Irie1994StimulatoryEO,
  title={Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase.},
  author={Kenji Irie and Yukiko Gotoh and B M Yashar and Beverly Errede and Eisuke Nishida and Kunihiro Matsumoto},
  journal={Science},
  year={1994},
  volume={265 5179},
  pages={1716-9}
}
Intracellular signaling from receptor tyrosine kinases in mammalian cells results in activation of a signal cascade that includes the guanine nucleotide-binding protein Ras and the protein kinases Raf, MEK [mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) kinase], and MAPK. MAPK activation that is dependent on the… CONTINUE READING