Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells.

@article{Chen2010StimulatoryEO,
  title={Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells.},
  author={Mei-Chih Chen and Shyi‐Wu Wang and S. Kan and S. Tsai and Yu-Ching Wu and Paulus S. Wang},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={118 2},
  pages={
          667-74
        }
}
Propylthiouracil (PTU) is a common and effective clinical medicine for the treatment of hyperthyroidism. Our previous study demonstrated that short-term treatment with PTU inhibits progesterone production in rat granulosa cells. However, our present results indicate that a 16-h treatment with PTU was able to stimulate pregnenolone production in rat granulosa cells, although progesterone production was diminished by PTU through inhibition of 3β-hydroxysteroid dehydrogenase. Notably, we found… Expand
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