Stimulatory effects of glucose and Porphyromonas gingivalis lipopolysaccharide on the secretion of inflammatory mediators from human macrophages.

@article{Hung2014StimulatoryEO,
  title={Stimulatory effects of glucose and Porphyromonas gingivalis lipopolysaccharide on the secretion of inflammatory mediators from human macrophages.},
  author={Shan Ling Hung and Nin-Gi Lee and L K Chang and Yen-Ting Chen and Yu-lin Lai},
  journal={Journal of periodontology},
  year={2014},
  volume={85 1},
  pages={140-9}
}
BACKGROUND Hyperglycemia is widely considered to be the causal link between diabetes mellitus (DM) and diabetic complications. The purpose of this study is to determine the effects of high glucose in the presence of lipopolysaccharide (LPS) purified from the periodontal pathogen Porphyromonas gingivalis on human macrophages. METHODS Macrophages (U937) were treated with various concentrations of P. gingivalis-LPS under normal (5.5 mM) or high (25 mM) glucose conditions. Mitochondrial… CONTINUE READING