Stimulatory effects of cholera toxin on arachidonic acid metabolism in Chinese hamster ovary cells.

@article{Reitmeyer1990StimulatoryEO,
  title={Stimulatory effects of cholera toxin on arachidonic acid metabolism in Chinese hamster ovary cells.},
  author={J. C. Reitmeyer and Johnny W. Peterson},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1990},
  volume={193 3},
  pages={181-4}
}
Cholera toxin (CT) stimulated the release of arachidonic acid (AA) from Chinese hamster ovary cells with no apparent lag period. CT-induced release of [3H]AA or its metabolites was dose dependent during a 4-hr period of toxin exposure with a minimum effective dose of 0.1 ng/ml. CT-induced release of [3H]AA metabolites began within 15 min of toxin addition and became maximal after approximately 5 hr. Neither CT-A subunit nor CT-B subunit alone caused [3H]AA release. Furthermore, [3H]AA release… CONTINUE READING