Stimulatory effects of HSR-803 on ileal motor activity.

  title={Stimulatory effects of HSR-803 on ileal motor activity.},
  author={Yuji Iwanaga and Nobuhiro Suzuki and Koki Kato and Toshifumi Kimura and Kouji Morikawa and Hideo Kato and Yushi Ito and Yasuo Gomi},
  journal={Japanese journal of pharmacology},
  volume={62 4},
Stimulatory effects of HSR-803 on intestinal motor activity in vitro were studied in guinea pig ileum. HSR-803 (1 x 10(-6)-1 x 10(-4) M) increased the amplitude of longitudinal muscle contractions and increased the frequency of peristalsis in isolated segments of guinea pig ileum. The stimulatory effect in amplitude and not frequency was abolished by 1 x 10(-6) M atropine. In the Magnus method with ileal segments, HSR-803 (1 x 10(-7) - 1 x 10(-4) M) produced contractions concentration… CONTINUE READING

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