Stimulatory effect on bone formation exerted by a modified chitosan.


A novel modified chitosan carrying covalently linked imidazole groups (average molecular weight 700,000, degree of substitution 0.28, degree of acetylation 0.08) was used to stimulate bone formation in an animal model. Lesions (7 mm diameter) were surgically made in the femoral condyle of sheep and treated with the modified chitosan. Within 40 d after… (More)


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@article{Muzzarelli1994StimulatoryEO, title={Stimulatory effect on bone formation exerted by a modified chitosan.}, author={Riccardo A. A. Muzzarelli and M. Mattioli-Belmonte and Caren Tietz and Raymond E. Biagini and G. Ferioli and Matteo Brunelli and Mary Elizabeth Fini and Richard Giardino and P K Ilari and G. Biagini}, journal={Biomaterials}, year={1994}, volume={15 13}, pages={1075-81} }