Stimulatory effect of fragments from transcribed region of ribosomal repeat on human peripheral blood lymphocytes

@article{Veiko2006StimulatoryEO,
  title={Stimulatory effect of fragments from transcribed region of ribosomal repeat on human peripheral blood lymphocytes},
  author={Nataliya N Veiko and Elena A Kalashnikova and Svetlana N Kokarovtseva and Svetlana V Kostyuk and Aleksei V. Ermakov and Svetlana M. Ivanova and T. A. Ryazantseva and Natalya A Egolina and N. A. Lyapunova and D. M. Spitkovskii},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2006},
  volume={142},
  pages={428-432}
}
Fragments from the transcribed region of the ribosomal repeat include considerable amounts of unmethylated CpG DNA motifs. These motifs activate immune cells via the interaction with Toll receptors. In vitro experiments confirmed the stimulatory effect of transcribed region of ribosomal repeat on human lymphocytes. Culturing of lymphocytes in a medium containing 2–20,000 ng/ml fragments from transcribed region of ribosomal repeat was accompanied by structural changes in the nucleus in a… CONTINUE READING

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