Stimulatory effect of endothelin-1 on neurons in the nucleus tractus solitarii is mediated by non-N-methyl-D-aspartate receptors.

@article{Shihara2001StimulatoryEO,
  title={Stimulatory effect of endothelin-1 on neurons in the nucleus tractus solitarii is mediated by non-N-methyl-D-aspartate receptors.},
  author={Miwako Shihara and Yoshitaka Hirooka and Kenichi Eshima and Nobuaki Hori and Akira Takeshita},
  journal={Hypertension research : official journal of the Japanese Society of Hypertension},
  year={2001},
  volume={24 2},
  pages={137-42}
}
We previously demonstrated that endothlin-1 (ET-1) augments and ETA receptor antagonist attenuates excitatory neuronal response to glutamate (Glu) in brainstem slices from normotensive rats. The aim of this study was to determine which type of Glu receptor is responsible for the stimulatory effects of ET-1 on neurons of the nucleus tractus solitarii (NTS). Single unit discharges were recorded extracellularly from rat brainstem slice preparations. Seven NTS neurons that were excited by solitary… CONTINUE READING