Stimulatory effect of bombesin on phosphoinositide metabolism in the rat pineal gland

  title={Stimulatory effect of bombesin on phosphoinositide metabolism in the rat pineal gland},
  author={R. Novotn{\'a} and I. Novotn{\'y}},
  journal={Neuroscience Letters},
The pineal gland is under complex peptidergic nervous control originating from hypothalamic nuclei. The daily rhythm of bombesin-like peptide in the hypothalamus suggests that this neuropeptide, similarly as other neuropeptides, might be involved in modulation of the physiological activity of the pineal gland. In our experiments we studied the mechanism of signal transduction of bombesin in the isolated pineal glands of rats. The phosphoinositide signalling system was examined by measuring 32P… Expand
Selective inhibition of β2‐adrenergic receptor‐mediated cAMP generation by activation of the P2Y2 receptor in mouse pineal gland tumor cells
One of the functions of P2Y2 receptors on the pineal gland is the selective inhibition of β‐adrenergic receptor‐mediated signaling pathways via the inhibitory G‐proteins, which is mediated by pertussis toxin‐sensitive Gi‐protein. Expand


Arginine vasopressin stimulates 32P labeling of phosphoinositides in rat pineal gland
The data indicate that AVP activates the phosphoinositide signaling system via V1 receptors and is without effect on the cAMP system. Expand
Pituitary hormones influence polyphosphoinositide metabolism in rat brain
It was of interest to investigate whether peptides influence brain membrane phospholipid metabolism, as it appears that they play a role in the Ca2+ influx into the cell. Expand
Interaction Between Adrenergic and Peptide Stimulation in the Rat Pineal: Pituitary Adenylate Cyclase‐Activating Peptide
Pineals from newborn rats respond to PACAP‐38 with an increase in NAT activity and the increase is augmented by concomitant α1‐adrenergic stimulation, which parallels changes in pineal NAT activity. Expand
Bombesin acts in the suprachiasmatic nucleus to affect circadian changes in tuberoinfundibular dopaminergic neuron activity and prolactin secretion.
It is concluded that bombesin may act on the rhythm generation center, the suprachiasmatic nucleus, to exert its effect to disrupt TIDA neuron activity and the PRL surge. Expand
Bombesin stimulates prolactin secretion from cultured rat pituitary tumour cells (GH4C1) via activation of phospholipase C
The results suggest that BBS stimulates PRL secretion from the GH4C1 cells via a mechanism involving the immediate formation of IP3 thus resembling the action of TRH, and both peptides caused a rapid and sustained increase in intracellular levels. Expand
Evidence for a role for protein kinase C in the modulation of bombesin-activated cellular signalling in human breast cancer cells
Data support an inhibitory role for PKC in the regulation of phosphoinositide hydrolysis and [Ca2+]i in breast cancer cells and provide a potential mechanism for feedback regulation of this signalling pathway in these cells. Expand
Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells.
Data strongly suggest that occupation of the bombesin receptor is closely coupled to activation of phospholipase A2 which results in the rapid release of arachidonic acid from phosphatidylcholine. Expand
Effect of bombesin on basal and stimulated secretion of some pituitary hormones in humans.
Bombesin affects in man, as in experimental animals, the secretion of some pituitary hormone levels, whereas LH and FSH levels after LHRH were higher. Expand
On the role of bombesin in homeostasis
Bombesin-like peptides and specific receptors have been characterized in the mammalian brain to regulate body temperature, gastrointestinal functions, blood glucose, pituitary ladrenal/gastric pancreatic hormone secretions as well as appetite and behavior. Expand
Photoneural regulation of the mammalian pineal gland.
  • D. Klein
  • Chemistry, Medicine
  • Ciba Foundation symposium
  • 1985
All the available evidence indicates that melatonin production is regulated by cyclic AMP. Expand