Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β.

  title={Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β.},
  author={Fumitaka Kawakami and Minori Suzuki and Naoki Shimada and Go Kagiya and Etsuro Ohta and Kei Tamura and Hiroko Maruyama and Takafumi Ichikawa},
  journal={The FEBS journal},
  volume={278 24},
Hyperphosphorylation of tau protein (tau) causes neurodegenerative diseases such as Alzheimer's disease (AD). Recent studies of the physiological correlation between tau and α-synuclein (α-SN) have demonstrated that: (a) phosphorylated tau is also present in Lewy bodies, which are cytoplasmic inclusions formed by abnormal aggregation of α-SN; and (b) the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) increases the phosphorylation of tau as well as the protein level of α-SN in… CONTINUE READING
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