Stimulatory and inhibitory effects of N-methyl-D-aspartate on 3H-inositol polyphosphate accumulation in rat cortical slices.

Abstract

The actions of the excitatory amino acid N-methyl-D-aspartate (NMDA) on the accumulation of 3H-inositol polyphosphate isomers in rat cerebral cortex slices have been examined over short (less than 5 min) incubation periods. NMDA caused the dose-dependent accumulation of only [3H]inositol monophosphate and [3H]inositol bisphosphate (maximal effect between 0… (More)

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