Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells.

@article{Okajima1998StimulatoryAI,
  title={Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells.},
  author={Fumikazu Okajima and Ken Sato and Hideaki Tomura and Atsushi Kuwabara and Hitoshi Nochi and Koichi Tamoto and Yoichi Kondo and Yukiko Tokumitsu and Michio Ui},
  journal={The Biochemical journal},
  year={1998},
  volume={336 ( Pt 2)},
  pages={491-500}
}
We examined the mechanism of action of lysophosphatidylcholine (LPC), which is suggested to be involved in the pathogenesis of atherosclerosis and inflammatory disorders, in HL-60 leukaemia cells. Extracellular 1-palmitoyl LPC increased the intracellular Ca2+ concentration in association with production of inositol phosphate. These actions of LPC were markedly inhibited by treatment of the cells with pertussis toxin and U73122, a phospholipase C inhibitor. The lipid-induced stimulation of the… CONTINUE READING

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