Stimulatory and cytotoxic effects of an antiserum to adipocyte plasma membranes on adipose tissue metabolism in vitro and in vivo.

@article{Flint1986StimulatoryAC,
  title={Stimulatory and cytotoxic effects of an antiserum to adipocyte plasma membranes on adipose tissue metabolism in vitro and in vivo.},
  author={David J. Flint and H Coggrave and C E Futter and Martin J Gardner and Tracy J Clarke},
  journal={International journal of obesity},
  year={1986},
  volume={10 1},
  pages={69-77}
}
Antibodies to rat adipocyte plasma membranes raised in sheep had a dual effect in vitro; at low concentrations they mimicked the actions of insulin whilst higher concentrations inhibited glucose incorporation into lipid. The insulin-like effects of the antibody appeared to be due to direct activation of the glucose transport system since the antibodies did not bind to the insulin receptor, as judged by their inability to immunoprecipitate the receptor or to inhibit insulin binding, and… CONTINUE READING
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