Stimulatory actions of a novel thiourea derivative on large-conductance, calcium-activated potassium channels.

Abstract

In this study, we examine whether an anti-inflammatory thiourea derivative, compound #326, actions on ion channels. The effects of compound #326 on Ca2+ -activated K+ channels were evaluated by patch-clamp recordings obtained in cell-attached, inside-out or whole-cell configuration. In pituitary GH3 cells, compound #326 increased the amplitude of Ca2… (More)
DOI: 10.1002/jcp.25788

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