Stimulatory action of internal protons on Slo1 BK channels.

  title={Stimulatory action of internal protons on Slo1 BK channels.},
  author={Vladimir Avdonin and Xiang Dong Tang and Toshinori Hoshi},
  journal={Biophysical journal},
  volume={84 5},
We investigated the internal pH-sensitivity of heterologously expressed hSlo1 BK channels. In the virtual absence of Ca(2+) and Mg(2+) to isolate the voltage-dependent gating transitions, low internal pH enhanced macroscopic hSlo1 currents by shifting the voltage-dependence of activation to more negative voltages. The activation time course was faster and the deactivation time course was slower with low pH. The estimated K(d) value of the stimulatory effect was approximately pH = 6.5 or 0.35… CONTINUE READING

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