Stimulative Effect of Cadmium on Prostaglandin E2Production in Primary Mouse Osteoblastic Cells

  title={Stimulative Effect of Cadmium on Prostaglandin E2Production in Primary Mouse Osteoblastic Cells},
  author={Tatsuro Miyahara and H. Tonoyama and Makoto M. Watanabe and Ai Okajima and Sawako Miyajima and Tutomu Sakuma and Nobuo Nemoto and Kiyoshi Takayama},
  journal={Calcified Tissue International},
We have reported that cadmium (Cd) stimulates bone resorption via prostaglandin E2 (PGE2), which is mainly produced in osteoblasts. Prostaglandin (PGs) is regulated by arachidonic acid (AA) release by phospholipase A2 (PLA2) and its conversion to PGs by cyclooxygenase (COX). In the present study, we investigated the possibility that Cd-induced PGE2 synthesis was mediated through PLA2 or COX or both using primary mouse osteoblastic cells in serum-free medium. Cd at 1 microM and above stimulated… CONTINUE READING
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