Stimulation of tumour cell dissemination by raised temperature (42°C) in rats with transplanted Yoshida tumours

@article{Dickson1974StimulationOT,
  title={Stimulation of tumour cell dissemination by raised temperature (42°C) in rats with transplanted Yoshida tumours},
  author={J. A. S. Dickson and Huw Ellis},
  journal={Nature},
  year={1974},
  volume={248},
  pages={354-358}
}
HYPERTHERMIA, that is, temperatures ≥40° C, may have a selective destructive effect on some types of cancer cells1,2, and sporadic attempts have been made to treat human cancer by raised temperatures1–3. Rossi-Fanelli and colleagues have demonstrated a selective and irreversible inhibition of metabolism in a variety of tumour cells at 42° C, whereas normal cells were unaffected1,4,5. These workers obtained histological regression of malignant limb tumours in patients treated by regional per… CONTINUE READING
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