Stimulation of tube formation mediated through the prostaglandin EP2 receptor in rat luteal endothelial cells.

@article{Sakurai2011StimulationOT,
  title={Stimulation of tube formation mediated through the prostaglandin EP2 receptor in rat luteal endothelial cells.},
  author={Toshihiro Sakurai and Kenta Suzuki and Mikihiro Yoshie and Keisuke Hashimoto and Eiichi Tachikawa and Kazuhiro Tamura},
  journal={The Journal of endocrinology},
  year={2011},
  volume={209 1},
  pages={33-43}
}
To explore the role of prostaglandin E(2) (PGE(2)) in angiogenesis in the developing corpus luteum, luteal microvascular endothelial-like cells (luteal ECs) were prepared from highly luteinizing ovaries of rats using the percoll density gradient method. The cells abundantly expressed the mRNAs of the endothelial markers CD31 (PECAM-1) and responded to the vascular endothelial growth factor (VEGF) to form in vitro tube structures on Matrigel. Cyclooxygenase (COX) inhibitors significantly… CONTINUE READING

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