Stimulation of transforming growth factor beta1 by enteric bacteria in the pathogenesis of rat intestinal fibrosis.

@article{Mourelle1998StimulationOT,
  title={Stimulation of transforming growth factor beta1 by enteric bacteria in the pathogenesis of rat intestinal fibrosis.},
  author={M. Lourdes Mourelle and Antonio Salas and Francisco Guarner and E. Paniagua Crespo and Ana Garc{\'i}a-Lafuente and J. R. Malagelada},
  journal={Gastroenterology},
  year={1998},
  volume={114 3},
  pages={519-26}
}
BACKGROUND & AIMS Bacteria and their products stimulate inflammatory responses. Certain mediators, such as transforming growth factor beta1 (TGF-beta1), induce collagen synthesis. Excess collagen deposition results in bowel strictures. The aim of this study was to investigate the role of bacteria and TGF-beta1 in the pathogenesis of intestinal fibrosis. METHODS In rats with colitis, the effects of bowel decontamination with antibiotics on TGF-beta1, tumor necrosis factor alpha (TNF-alpha… CONTINUE READING

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