Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences.

@article{Heggelund2004StimulationOT,
  title={Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences.},
  author={Lars Heggelund and Jan Kristian Dam{\aa}s and Arne Yndestad and Are Martin Holm and Fredrik Muller and Egil Lien and Terje Espevik and P{\aa}l Aukrust and Stig Sophus Fr\oland},
  journal={Clinical and experimental immunology},
  year={2004},
  volume={138 1},
  pages={116-21}
}
Toll-like receptor 2 (TLR2) stimulation in monocytes may contribute to enhanced inflammation and viral replication in HIV infection. In the present study we examined if TLR2 stimulation could modulate chemokine responses in peripheral blood mononuclear cells (PBMC) from HIV-infected patients and healthy controls. Our main findings were, with similar qualitative patterns in both healthy controls and HIV-infected patients: (1) TLR2 stimulation induced up-regulation of several chemokines at the… CONTINUE READING

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