Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation.

@article{Arts1995StimulationOT,
  title={Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation.},
  author={Janine Arts and Mirian Lansink and J. Grimbergen and Karin H. Toet and Teake Kooistra},
  journal={The Biochemical journal},
  year={1995},
  volume={310 ( Pt 1)},
  pages={171-6}
}
We have previously shown that the pleiotropic agent sodium butyrate strongly stimulates tissue-type plasminogen activator (t-PA) expression in human umbilical vein endothelial cells (HUVEC). Here we provide the following evidence that the butyrate-induced t-PA expression in HUVEC involves histone H4 acetylation. (1) t-PA induction by butyrate occurs at the transcriptional level and does not require new protein synthesis, indicating a direct effect. (2) t-PA induction by butyrate can be fully… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Dual mechanisms for the regulation of brain-derived neurotrophic factor by valproic acid in neural progenitor cells

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…