Stimulation of the preprothyrotropin-releasing hormone gene by epidermal growth factor.

@article{Ren1998StimulationOT,
  title={Stimulation of the preprothyrotropin-releasing hormone gene by epidermal growth factor.},
  author={Y Ren and Teturou Satoh and Masanobu Yamada and Koshi Hashimoto and Setsuko Konaka and Tetsushi Iwasaki and Masatomo Mori},
  journal={Endocrinology},
  year={1998},
  volume={139 1},
  pages={195-203}
}
Regulation of the expression of the prepro-TRH (ppTRH) gene by epidermal growth factor (EGF) was investigated. The i.p. injection of EGF significantly stimulated hypothalamic ppTRH messenger RNA levels in rats. To clarify whether this stimulatory effect of EGF could be exerted at the level of gene transcription, the 5'-flanking region (-1893/+127) of the mouse ppTRH gene fused to a luciferase reporter gene was transiently transfected into pituitary GH4C1 cells, and the effect of EGF on gene… CONTINUE READING

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