Stimulation of the phosphatidylinositol pathway can induce T-cell activation.

  title={Stimulation of the phosphatidylinositol pathway can induce T-cell activation.},
  author={Dev M. Desai and Marianne E. Newton and Theresa A. Kadlecek and Arthur. Weiss},
  volume={348 6296},
The T-cell antigen receptor (TCR) regulates two signal transduction pathways: the phosphatidylinositol (PtdIns) and tyrosine kinase pathways. Stimulation of T cells with antigen or anti-TCR monoclonal antibodies induces an increase in inositol phosphates and diacylglycerol, the second messengers responsible for the mobilization of cytoplasmic free calcium and activation of protein kinase C-4. The TCR also activates a tyrosine kinase that is not intrinsic to the TCR. The relationship between… CONTINUE READING
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