Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

@inproceedings{Colombo2012StimulationOT,
  title={Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration},
  author={Emanuela Colombo and Chiara Cordiglieri and Giorgia Melli and Jia Newcombe and Markus Krumbholz and Luis F Parada and Enzo Medico and Reinhard Hohlfeld and Edgar Meinl and Cinthia Farina},
  booktitle={The Journal of experimental medicine},
  year={2012}
}
Neurotrophin growth factors support neuronal survival and function. In this study, we show that the expression of the neurotrophin receptor TrkB is induced on astrocytes in white matter lesions in multiple sclerosis (MS) patients and mice with experimental autoimmune encephalomyelitis (EAE). Surprisingly, mice lacking TrkB specifically in astrocytes were protected from EAE-induced neurodegeneration. In an in vitro assay, astrocytes stimulated with the TrkB agonist brain-derived neurotrophic… CONTINUE READING

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