Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment

@article{Harich2007StimulationOT,
  title={Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment},
  author={Silke Harich and Gerhard Gross and Anton Bespalov},
  journal={Psychopharmacology},
  year={2007},
  volume={192},
  pages={511-519}
}
RationaleGlutamatergic mechanisms are implicated in psychiatric disorders such as schizophrenia. Modulation of glutamatergic neurotransmission via stimulation of the metabotropic glutamate 2/3 receptors (mGluR2/3) has been shown to reverse a number of behavioral effects of NMDA receptor antagonists thus indicating potential antipsychotic activity of mGluR2/3 agonists.ObjectivesThe present study aimed to evaluate the effects of LY-354740 (mGluR2/3 agonist) and LY-487379 (mGluR2 potentiator) on… 
Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine
TLDR
MGluR5 PAMs not only reverse but also prevent the emergence of cognitive impairment associated with a developmental model of schizophrenia, as evaluated by a SND procedure.
Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition
TLDR
Evaluating the effect of the mGluR2/3 agonist, LY354740 in animal models relevant to both psychotic and cognitive impairment in schizophrenia concluded that it was effective in models for anxiety and positive symptoms of schizophrenia but not in Models for sensorimotor gating and Cognitive impairment.
Stimulation of metabotropic glutamate (mGlu) 2 receptor and blockade of mGlu1 receptor improve social memory impairment elicited by MK-801 in rats.
TLDR
Findings indicate that both the stimulation of the mGlu2 receptor and the inhibition of an mGLU1 receptor improve social memory impairment elicited by MK-801, and both manipulations could be effective approaches for the treatment of certain cognitive dysfunctions observed in schizophrenic patients.
mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia
TLDR
It is demonstrated that the mGluR2/3 agonist LY379268 restores excitatory and inhibitory deficits with similar efficiency as olanzapine in the two-hit schizophrenia mouse model, which significantly contributes to the understanding of the mechanisms underlying the therapeutic effects of Ly379268 and supports the use of agents aimed at mGlamorganic glutamate receptors.
d-Serine and a glycine transporter-1 inhibitor enhance social memory in rats
RationaleGlutamatergic abnormalities are involved in the etiology of schizophrenia. Clinical evidence demonstrates that positive modulation of “glycine modulatory sites” on N-methyl-d-aspartic acid
Effects of a Positive Allosteric Modulator of Group II Metabotropic Glutamate Receptors, LY487379, on Cognitive Flexibility and Impulsive-Like Responding in Rats
TLDR
It is demonstrated that a mGluR2 PAM, LY487379, promotes cognitive flexibility and facilitates behavioral inhibition, which may contribute to the therapeutic efficacy of agents stimulating mGLUR2 in schizophrenia.
Reversal of MK-801-Induced Disruptions in Social Interactions and Working Memory with Simultaneous Administration of LY487379 and VU152100 in Mice
TLDR
The data show that modulation of M4 and mGlu2 receptors may potentially be beneficial in the treatment of negative and cognitive symptoms of schizophrenia.
Neonatal phencyclidine and social isolation in the rat: effects of clozapine on locomotor activity, social recognition, prepulse inhibition, and executive functions deficits.
TLDR
The PCP-SI model presents enduring and robust deficits (hyperactivity and social recognition impairment) associated with positive symptoms and cognitive/social deficits of schizophrenia, respectively that are normalized by chronic treatment with clozapine, thereby confirming the predictive validity of this animal model.
Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat
TLDR
Preclinical data, from acute and neurodevelopmental models, suggest that GlyT1 inhibition may exhibit activity in the positive, negative, and cognitive symptom domains of schizophrenia.
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