Stimulation of the metabotropic glutamate (mGlu) 2 receptor attenuates the MK-801-induced increase in the immobility time in the forced swimming test in rats.

@article{Kawaura2016StimulationOT,
  title={Stimulation of the metabotropic glutamate (mGlu) 2 receptor attenuates the MK-801-induced increase in the immobility time in the forced swimming test in rats.},
  author={Kazuaki Kawaura and Jun-ichi Karasawa and Hirohiko Hikichi},
  journal={Pharmacological reports : PR},
  year={2016},
  volume={68 1},
  pages={
          80-4
        }
}
BACKGROUND Negative symptoms of schizophrenia are poorly managed using the currently available antipsychotics. Previous studies indicate that agonists of the metabotropic glutamate (mGlu) 2/3 receptors may provide a novel approach for the treatment of schizophrenia. However, the effects of mGlu2/3 receptor agonists or mGlu2 receptor positive allosteric modulators have not yet been clearly elucidated in animal models of the negative symptoms of schizophrenia. Recently, we reported that the… CONTINUE READING

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