Stimulation of the hypothalamic ventromedial nuclei by pituitary adenylate cyclase-activating polypeptide induces hypophagia and thermogenesis.

@article{Resch2011StimulationOT,
  title={Stimulation of the hypothalamic ventromedial nuclei by pituitary adenylate cyclase-activating polypeptide induces hypophagia and thermogenesis.},
  author={Jon M. Resch and Joanne P Boisvert and Allison E Hourigan and Christopher R. Mueller and Sun Shin Yi and Sujean Choi},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2011},
  volume={301 6},
  pages={R1625-34}
}
Numerous studies have demonstrated that the hypothalamic ventromedial nuclei (VMN) regulate energy homeostasis by integrating and utilizing behavioral and metabolic mechanisms. The VMN heavily express pituitary adenylate cyclase-activating polypeptide (PACAP) type I receptors (PAC1R). Despite the receptor distribution, most PACAP experiments investigating affects on feeding have focused on intracerebroventricular administration or global knockout mice. To identify the specific contribution of… CONTINUE READING
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