Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase.

  title={Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase.},
  author={T Ruscetti and Bruce E. Lehnert and James Halbrook and H Le Trong and Merl F. Hoekstra and David J. Chen and Scott R Peterson},
  journal={The Journal of biological chemistry},
  volume={273 23},
The DNA-dependent protein kinase (DNA-PK) is a heterotrimeric enzyme that binds to double-stranded DNA and is required for the rejoining of double-stranded DNA breaks in mammalian cells. It has been proposed that DNA-PK functions in this DNA repair pathway by binding to the ends of broken DNA molecules and phosphorylating proteins that bind to the damaged DNA ends. Another enzyme that binds to DNA strand breaks and may also function in the cellular response to DNA damage is the poly(ADP-ribose… CONTINUE READING