Stimulation of secretion by the T84 colonic epithelial cell line with dietary flavonols.

@article{Nguyen1991StimulationOS,
  title={Stimulation of secretion by the T84 colonic epithelial cell line with dietary flavonols.},
  author={T. D. Nguyen and Andrew T. Canada and Greg Heintz and Thomas W. Gettys and Jonathan A. Cohn},
  journal={Biochemical pharmacology},
  year={1991},
  volume={41 12},
  pages={
          1879-86
        }
}
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47 Citations
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47 Citations

Effects of quercetin on epithelial chloride secretion.

Dietary flavonol quercetin induces chloride secretion in rat colon.

It is demonstrated that the dietary flavonol quercetin induces Cl- secretion and most likely HCO-3 secretion in rat small and large intestine.

The Secretory Response of the Rat Colon to the Flavonol Quercetin is Dependent on Ca2+‐Calmodulin

Results indicate that the chloride secretion induced by quercetin in rat colon depends on Ca2+ and calmodulin, and the cAMP pathway and inhibition of phosphodiesterase appear not to be responsible for the secretory activity of the flavonol.

Effect of the flavonol quercetin on ion transport in the isolated intestine of the eel, Anguilla anguilla.

The Chemopreventive Agent Resveratrol Stimulates Cyclic AMP–Dependent Chloride Secretion In vitro

The main mechanism of action of resveratrol in intestinal epithelia is cAMP-induced chloride secretion which can be suppressed by butyrate, suggesting that in cancer chemoprevention, both agents should be combined to reduce an undesired side effect such as diarrhea and to benefit from the known agonistic effect of both agents on differentiation of colon cancer cells.

Flavonoids stimulate Cl conductance of human airway epithelium in vitro and in vivo.

The ability of the flavonoids genistein, apigenin, kaempferol, and quercetin to activate cystic fibrosis transmembrane conductance regulator-mediated Cl currents in human airway epithelium was investigated and data imply that the activation kinetics and the binding site(s) for flavonoid were significantly altered by forskolin stimulation.

Nobiletin Stimulates Chloride Secretion in Human Bronchial Epithelia via a cAMP/PKA-Dependent Pathway

The mechanisms involved activation of adenylate cyclase- and cAMP/PKA-dependent pathways, leading to activation of apical CFTR Cl- channels, and stimulated transepithelial Cl- secretion across human bronchial epithelia.

The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.

Actions of Quercetin, a Polyphenol, on Blood Pressure

Novel, unique mechanisms of quercetin’s anti-hypertensive action via activation of NKCC1 are introduced in detail.

Effects of flavonoids on gastrointestinal disorders

References

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