Stimulation of pulmonary C fibres decreases coronary arterial resistance in dogs.

  title={Stimulation of pulmonary C fibres decreases coronary arterial resistance in dogs.},
  author={George A. Ordway and Kenneth H. Pitetti},
  journal={The Journal of Physiology},
A constant‐flow preparation was used to assess coronary arterial resistance while activating pulmonary C fibres in chloralose‐anaesthetized dogs. A Gregg cannula was passed through the left common carotid artery until the tip fitted snugly in the left circumflex coronary artery. The cannula was perfused with blood from the left femoral artery and blood flow through the cannula was maintained constant with a perfusion pump. Perfusion pressure in the coronary artery was measured from a side arm… 

Reflex coronary vasodilation evoked by chemical stimulation of cardiac afferent vagal C fibres in dogs.

Coronary vasodilatation can be evoked by selective stimulation of cardiac chemosensitive vagal C fibres, although the coronary vasodilation of the veratridine‐induced Bezold‐Jarisch reflex may be due to stimulation of both mechanosensitive and chemossensitive C fibre.

Neural Control of Coronary Blood Flow

  • E. Feigl
  • Medicine, Biology
    Journal of Vascular Research
  • 1998
Evidence indicates that there is a beneficial effect of this paradoxical vasoconstrictor influence in that it helps preserve flow to the vulnerable inner layer of the left ventricle, but only when both heart rate and coronary flow are high.

Microvascular dilation evoked by chemical stimulation of C-fibers in rats.

Pulmonary C-fibers can exert an inhibitory influence on neural tone of the microcirculation at an important site where microvascular resistance and tissue blood flow are regulated.

Autonomic Control of Coronary Blood Flow

Coronary vasodilation secondary to the intracoronary infusion of acetylcholine depends upon functioning endothelial cells to produce endothelium-derived relaxing factor, suggesting that the loss of endothelial function is an early marker for atherosclerosis.

Regulation of Coronary Blood Flow.

Current knowledge regarding the physiologic regulation of coronary blood flow is highlighted, with emphasis on functional anatomy and the interplay between the physical and biological determinants of myocardial oxygen delivery.

The central control of the pulmonary chemoreflex

The results of vagal stimulation experiments demonstrate that both populations of cardiac vagal preganglionic neurones have chronotropic action in the cat, rat and rabbit, and both populations are implicated in the pulmonary chemoreflex.

Reflex effects on the coronary circulation

  • D. Mary
  • Biology, Medicine
    Experimental physiology
  • 1992
This review focuses on the reflex effects of the stimulation of cardiovascular and visceral receptors on the coronary circulation and factors influencing the cardiac metabolism and physical, humoral, and neural mechanisms.

Pulmonary Stress Induced by Hyperthermia: Role of Airway Sensory Nerves

These studies, once completed, should provide important and novel information for documenting the pulmonary stresses induced by hyperthermia in healthy individuals and in patients with sensitized airways; understanding the mechanism underlying thehyperthermia-induced pulmonary dysfunction; and detecting the susceptibility to heat stress in soldiers with underestimated or overlooked airway hypersensitivity such as in airway allergy or mild asthma.



Carotid Baroreceptor Reflex Coronary Vasodilation in the Dog

It is concluded that carotid sinus hypertension results in a graded reflex neural coronary vasodilation independent of myocardial metabolic factors.

Alpha-adrenergic regulation of the coronary circulation in the conscious dog.

  • S. Vatner
  • Medicine, Biology
    The American journal of cardiology
  • 1983

Dependency of myocardial reactive hyperemia on coronary artery pressure in the dog.

The observed pressure dependency suggests that coronary reactive hyperemia may be, in part, a passive flow response that could be explained by a transient depression of the normal vascular reactivity to postocclusion pressure.

Regulation of Coronary Blood Flow during Individual Diastoles in the Dog

During constant pressure perfusion, diastolic coronary vascular resistance is constant during diastole, and when coronary resistance is actively changing, regulation of coronary blood flow occurs continuously during individual diastoles.

α‐Adrenergic‐Mediated Reduction in Coronary Blood Flow Secondary to Carotid Chemoreceptor Reflex Activation in Conscious Dogs

It is concluded that, with autonomic nervous system activity intact, carotid chemoreceptor reflex activation can elicit an absolute reflexly mediated reduction in coronary blood flow in the normal, conscious dog, despite an increase in arterial pressure.

Reflex Parasympathetic Coronary Vasodilation Elicited from Cardiac Receptors in the Dog

  • E. Feigl
  • Medicine, Biology
    Circulation research
  • 1975
It is concluded that a cardiocoronary reflex parasympathetic coronary vasodilation can be elicited by stimulating cardiac receptors with veratridine.


The reciprocal relation between the atrial rate and the coronary vascular tone may indicate a vagal coronary dilator and a sympathetic coronary constrictor effect in the dog.

Interaction of the Chemoreflex and the Pulmonary Inflation Reflex in the Regulation of Coronary Circulation in Conscious Dogs

Nicotine stimulation of the carotid chemoreflex results in a striking coronary dilation that has two components: the major component follows an increase in the depth of respiration, and its efferent component appears to involve withdrawal of alpha-adrenergic constrictor tone.

Reflex cardiovascular response during injection of capsaicin into skeletal muscle.

In an anesthetized dog, injections of capsaicin into a neurally intact donor-perfused hindlimb produced a significant increase in mean aortic pressure, heart rate, cardiac output, and respiratory minute volume, which are similar to those that occur during induced isometric exercise in the hindlimbs.

Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs.

The afferent fibres described in the present paper were encountered in the course of this work and were the only pulmonary fibres consistently stimulated by capsaicin, the drug having little or no effect on the activity of pulmonary stretch fibres of the type described by Adrian (1933).